An IACUC approved protocol may be required for animal tissue and fluids if the animal is procured or euthanized for research, testing, or teaching purposes or if manipulation of the live vertebrate animal occurs for research, testing, or teaching purposes. Approval is valid for a maximum of 3 years. * IMPORTANT CHANGE IN PROTOCOL REVIEW REQUIREMENTS: Starting in October, 2019, the ACUC will ONLY require the review of all Third Year Protocols, all … Email: acuoffice@umich.edu, HUSBANDRY & VETERINARY CARE Previous studies looking at the same condition/problem: Include what has been … The Institutional Animal Care & Use Committee (IACUC) will begin its next round of semi-annual facility inspections on Tuesday, February 2, 2021. The protocol helps you clarify the work ahead and helps investors and collaborators outside the project to understand it. Nevertheless, research is continuing into finding new ways to further promote the 3Rs scheme – to "reduce, refine and replace" the use of animals in research. View a list of Animal Care Manuals today. Introduction. A research protocol is a detailed explanation of your research project: your goals, the details of your research and how you'll protect the welfare researchers and volunteers. Once these cells have been produced there are options for both in-vivo and in-vitro production of large volumes of the antibody. Animal Use Protocol Texas A&M University is committed to maintaining high standards for the care and use of animals in its research, testing, and teaching programs. “Animal research has improved the health and welfare of animals and humans. Prepared by HARC for OSPIP and the funding agencies 3. Sample Literature Searches for … Animal Research Review Panel . The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) are a checklist of recommendations to improve the reporting of research involving animals – maximising the quality and reliability of published research, and enabling others to better scrutinise, evaluate and reproduce it. Australian/New Zealand Standard (2010) Standard AS-NZS 2243-3:2010. Search for step-by-step, detailed descriptions of procedures pertaining to proper animal care and use. Ensuring the health and safety of research personnel and the animals entrusted to our care is critical to the long-term sustainability of a strong Animal Care & Use Program. Find standard acceptable animal euthanasia methods based on guidelines from the American Veterinary Medical Association (AVMA).Mice, rats, gerbils, hamsters, or other small rodentsCarbon dioxide (CO2)Inhalation to effect. Phone: (734) 764-0277 In the United States, the rules and forms required are typically set by the schools Institutional Animal Care and Use Committee (IACUC). Animal Care and Use. From above example, note that the classifications go from general (Animalia) to specific (C. lupus). Title: Principal Investigator: Other Investigators: Institutional affiliations: I. 4 Rationale 6 Procedures 8 Alternative Search 20 Procedure Relationships 21 Husbandry 22 Animal Disposition 25 Certifications 26. No animal research can be done without a strong potential for benefits to animals and/or humans. The federally mandated Institutional Animal Care and Use Committee (IACUC) at KSU is the Animal Care and Use Committee (IACUC). To save time and decrease the chance of the protocol being delayed in review, the IACUC encourages people to … The Institutional Animal Care and Use Committee (IACUC) and Animal Resource Center (ARC) oversee the university’s animal programs, facilities and procedures ensuring the appropriate care, use and humane treatment of animals being used for research, testing and education. For either oral or parenteral supplementation, if the underlying disease process has resolved and cobalamin body stores have been replenished, serum cobalamin concentration should be supranormal at the time of reevaluation. GUIDANCE & OVERSIGHT Once completed, the AZA Conservation, Management, & Welfare Sciences Department will provide final approval and post the ACM on the AZA website accordingly. Changes to the policy include (1) the applicability of the policy to individuals of all ages, (2) 1, 2nd Edn., 1993. Exclusion criteria may also reflect the ethical principles of a study in line with its humane endpoints (see Item 16. Drexel University. The Office of Animal Welfare will be implementing the electronic system for IACUC protocol submission and review via the Kuali program shortly. Prolonged exposure may be required for neonates and fetuses.Sodium pentobarbital≥100 Cultural competence is widely seen as a foundational pillar for reducing disparities through culturally sensitive and unbiased quality care. Animals, usually mice, are needed to produce these monoclonal antibody producing cells. The conversion on such a protocol should occur approximately a week after the completed action. Flow rate must displace no more than 30% of the chamber volume/minute. Animal Study Proposal v12/8/2015 1 ... in the use of professional judgment and avoid non-compliance due to work conducted off protocol as a result of overly restricted parameters. PROTOCOL Animal Use Protocol Berkeley Protocol # AUP-2020-05-13318 Date Printed: 05/22/2020 Personnel Information 1 Species 3 Are You Using? Proponents, however, insist that animal research has played, and is continuing to play, a vital role in treating and preventing many illnesses and diseases once thought incurable. To the greatest extent possible, pre-emptive euthanasia should be advocated for any study in which an animal is likely to progress to a moribund state (impending death). While feline anesthesia is a routine procedure in many veterinary practices, studies show that the likelihood of anesthetic mortality is higher in cats than it is in dogs. IACUC protocols must be submitted to … A complete ACM Template is available to all AZA members. Ancestry testing is $50 per animal, payable by check/money order made out to Texas Agrilife Research – VTAN. Reducing health disparities and achieving equitable health care remains an important goal for the U.S. healthcare system. Abstract. In the 10 years since publication, the ARRIVE guidelines have been endorsed by more than a thousand journals from across the life sciences. Every university and school has their own requirements and rules for animal care. Animals held under proper captive conditions or wild animals that are being observed. National Institutes of Health (NIH), OLAW: Animal Study Proposal Each section lists bulleted points, developed with input from AZA Committees, Scientific Advisory Groups, and the Animal Program's Population Management and Reproductive Management Centers, that are addressed by the authors. A Spec 20 was used to measure A 600 of Tubes 1,2, and 3 immediately after chloroplasts were added (Time 0) and every 2 min. Enter your search query in the field below. Safety in laboratories – Microbiological Safety and Containment The following classification has been drawn up for microorganisms that are infectious for humans and animals for Australia and New Zealand by modification of the WHO guidelines and is based on the pathogenicity of the agent, the mode of … CO 2 (Carbon Dioxide Gas) - Special Considerations for the use of CO 2 as a euthanasia agent: . Begin with our Project Lifecycle, D16-00072 (A3114-01), Assurance Dates: July 2017 - July 2021, 34-R-0001, Last Inspection Date: September 16, 2020. Quick access to the animal care and use forms needed to complete your day-to-day research operations. In a clinical trial (also called an interventional study), participants receive specific interventions according to the research plan or protocol created by the investigators. For example scientists often use wording or jargon commonly used in grant proposals or simply copy the research plan of a grant into the animal activity proposal. 412 Victor Vaughan Animal use protocol sample: overview of the procedure for mouse hybridoma production Hybridomas are permanent cell lines that secrete monoclonal antibodies. Our turnaround time is two weeks once the sample is received in the lab for testing. Laboratory Animal Use Protocol: use for any laboratory-related species such as mice, rats, rabbits, guinea pigs, etc. HRPO Submission Form -- Secondary Research Involving the Use of Data/Specimens (32 KB) International Research Study Information Form (72 KB) Site-Specific Protocol Addendum (25 KB) ORP Cadaver Submission Form (32 KB) Army Policy for Use of Human Cadavers for Research Development, Test and Evaluation, Education or Training (146 KB) ACMs are considered works in progress, since practices continue to evolve through advances in scientific knowledge. BACKGROUND AND SIGNIFICANCE. AZA Animal Care Manuals (ACMs) provide a compilation of animal care and management knowledge that has been gained from recognized species experts, including AZA Taxon Advisory Groups (TAGs), Species Survival Plan® Programs (SSPs), biologists, veterinarians, nutritionists, reproduction physiologists, behaviorists and researchers. B. animal-use protocol template in AR 40-33 / AFMAN 40-401(I), Appendix C). Protocol: weekly injections for 6 weeks, then one dose a month later, and retesting one month after the last dose. The new system will allow faculty, researchers and staff to submit new animal protocols, and to modify these new protocols. There are 3 different Animal Use Protocols to choose from depending upon the type of animal research to be conducted. For example, if you submitted an amendment to the protocol that has not been approved by the time of the conversion, the protocol record would not move over to the new system until after the IRB has completed the action on the protocol. Writing an Animal Protocol Wantanee Ratanasak DVM, MSc Wantanee.rat@mahidol.ac.th The Research Proposal • Before a research program can begin, the scientist must write a detailed outline of the proposed research. Unit for Laboratory Animal Medicine (ULAM) ... • WHO has developed a protocol for the investigation of early cases (the “First Few X (FFX) Cases and contact These interventions may be medical products, such as drugs or devices, procedures or changes to participants’ behavior, for example, diet. Description. Generally, before experiments on animals are conducted, the research protocol must be reviewed by animal ethics committees. This varied expertise can be used to enhance animal care and welfare, which includes the physical, psychological, and emotional health of our animals. Animal care and monitoring). The eIACUC can be accessed at in the ARC Portal. Please review the information on this page and submit all documents to IACUC@mail.wvu.edu. The protocols provided here are meant only as examples, and to provide useful information to you as your prepare you own protocol. To draft a sound scientific design of a clinical research study, the medical writer at the TGH, Office of Clinical Research recommends that the following information should be included in a research protocol. The TAG or SSP will identify an ACM Coordinator to serve as the main communications conduit between the authors and AZA's Animal Welfare Committee (AWC) and Conservation, Management, & Welfare Sciences Department. Tips for Searching for Alternatives to Animal Research and Testing View slides from the workshop given by the USDA on Meeting the Information Requirements of the Animal Welfare Act. This policy revises previous policy and guidelines regarding the inclusion of children in research. The use of information within the manuals should be in accordance with all local, state, and federal laws and regulations concerning the care of animals. For a list of all ACC policies and procedures, please visit the Research & teaching with animals website. The guiding principle of these committees is usually the 3 Rs. Our team is available on campus and remotely to continue the provision of services that ensure animal welfare and support the U-M research community. For example, The Lupus and APS Center at Hospital for Special Surgery conducts research to learn more about lupus and/or antiphospholipid antibody syndrome (APS). Review high-level program plans, goals, and acceptable animal care and use procedures to remain in good standing. UW’s Office of Animal Welfare (OAW) is responsible for reviewing and approving protocols. The ACM Coordinator should include any relevant Scientific Advisory Groups (SAGs) to assist with writing and reviewing those specific sections of the ACMs. Procedure. Department of Small Animal Clinical Sciences (VSCS) Texas A&M College of Veterinary Medicine & Biomedical Sciences 4474 TAMU | College Station, TX 77843-4474 Tel: 979.845.2351 | Fax: 979.845.6978 Web: vscs.tamu.edu Classification C: Animals upon which teaching, research, experiments, or tests will be conducted involving no pain, distress, or use of pain-relieving drugs. To help establish... Several service areas within the Animal Care & Use Program, including the Animal Care & Use Office (ACUO) and the Unit for Laboratory Animal Medicine (ULAM) will be closed or operating at... As part of our long-standing commitment to the 3Rs principles of biomedical research, the Unit for Laboratory Animal Medicine (ULAM) is pleased to announce the return of the. Be sure to indicate the specific activity each member of the team will perform on the AUP. Georgetown University. Intervention includes both physical procedures by which data are gathered (for example, venipuncture) and manipulations of the subject or the subject’s environment that are performed for research purposes. Fax: (734) 936-3235 Either template may be used to format DOD-sponsored animal research proposals; however, unless highly experienced in using the template without the provided instructions, it is preferable to enter the requested information directly into this document. Background information on condition or problem to be studied: Include incidence, typical characterization of the condition, etc. Action is taken as per the study protocol and includes euthanizing the animal, stopping a painful procedure, or alleviating the pain or distress with other appropriate measures. A. Everyone handling animals for the purpose of animal research must be listed on an IACUC protocol. Canis lupus is a species. The protocol will continue being reviewed but will remain pending approval until favourable peer reviews have been supplied. Low invasive estrous synchronization protocol for wild animals: an example with melengestrol acetate in brown brocket deer (Mazama gouazoubira) October 2020 Animal Reproduction 17(4):e20200526 David Fraser, in Advances in Agricultural Animal Welfare, 2018. A clinical study uses research with human participants. The IACUC is responsible for reviewing and approving protocols. Institutional Animal Care and Use Committee Protocol Form Instructions T h efor mi s dula n c t .AC ( ) b p y Attachments may need to be completed depending on your responses to the checklist in Section V of the Core. For example, recommendation for linseed inclusion to diet (for improving reproduction performance or modifying milk FA) is up to 10% of DM (you can refer to Petit et al., 2010- … Animal research facility The facility should be designed and operated to control selected parameters (such as temperature, humidity and light) to minimize the effects of environmental variables on the animal. Problematic example: In this example the reader will have no clue as to what the various tubes represent without having to constantly refer back to some previous point in the Methods. " animal protocols approved for this research 2. Click the X to close. Completed Animal Care Manuals include: The development of each ACM is coordinated by the AZA Animal Welfare Committee and managed by AZA's Conservation, Management, & Welfare Sciences Department. The Association of Zoos & Aquariums offers Animal Care Manuals (ACMs) created by leading biologists, veterinarians, nutritionists, reproduction physiologists, behaviorists and researchers to equip zoo and aquarium employees and volunteers with comprehensive care guides for various species. Find suggested parameters for a variety of tasks related to animal care and use research duties. The modern horse was … Research is a systematic investigation to establish facts or principles, or to collect information on a subject. 2800 Plymouth Road If you continue using our website, we'll assume that you are happy to receive all cookies on this website and you agree to our Privacy Policy. For example, we can use the term gray wolf but we cannot use just Canis or lupus to describe this animal. To be on a protocol, there are several items that need to be completed. Texas A&M has adopted the “U.S. First, animal experiments must be replaced wherever possible by other methods such as mathematical modeling, or an in vitro biological system. Gas should be delivered using a gradual fill method- a displacement rate from 30% to 70% of the chamber volume per minute is recommended. Medical SOPs: lifesaving, step by step - Animal Sheltering Online by The Humane Society of the United States From Animal Sheltering magazine September/October 2012 By Miranda Spindel, D.V.M., M.S. Animal research is a good case in point, ... for example, for observational research, studies conducted in the field, and where animal tissues are used. The ACM Coordinator will work with the authors to compile all scientific data and professional information about the natural history and management strategies of the taxa and will incorporate this information into the pre-existing sections of the ACM template. A brief description of the animal activities planned for the 4 th and 5 th year of the award period should be provided in the animal protocol recognizing that the experimental details and procedures will be refined or amended at … ACUO is a unit of the U-M Office of Research: ULAM is a unit of the Medical School Office of Research: Continuing Education & Supplemental Training, Laboratory Animal Research Coordinator Certification Program, Anesthetic Machine Certification & Rental, Refinement & Enrichment Advancements Laboratory, COVID-19: Guiding Principles for Working Safely with Research Animals in the Vivarium webpage, Frequently Required Grant Information and Data, Winter 2021 Semi-Annual IACUC Facility Inspections Begin, Download the Complete Winter 2021 Inspection Schedule (Level-1 login required), Winter 2021 Semi-Annual IACUC Facility Inspections Conclude, Expected Adherence to New & Revised Procedures Outlined in the Hazardous Agents Administration SOP, Read the Hazardous Agents Administration SOP in its Entirety, IACUC Semi-Annual Inspections Begin Tuesday, February 2, Updates to Hazardous Agents Administration SOP, ULAM, ACUO Announce Winter 2020 Holiday Hours, ULAM Relaunches Program for Rat Donation and Redistribution. Examples: Sample Research Protocol Template Published Sep 13, 2016. Writing an animal … Email: ulam-questions@umich.edu, Our team is available on campus and remotely to continue the provision of services that ensure animal welfare and support the U-M research community. Large animal species such as rabbits, pigs, sheep, cows, cats and ferrets: at least two different items from the species' approved enrichment database should be provided to singly housed large animals. It will help facilitate the application submission process and study approval from the Office of Clinical Research and IRB. Posted Date. b. Wildlife Laboratory Animal Use Protocol: use for wildlife field studies. Submission of Protocols. Office of Sponsored Projects & Industry Partnerships Human and Animal Regulatory Committee Office How to … Ann Arbor, MI 48109 Phone: (734) 763-8028 The success or failure of a research protocol depends on the quality of data collected during experimental procedures. CO 2 must be delivered from compressed gas canister only. In 2018 the American Association of Feline Practitioners (AAFP) issued new safety guidelines in an effort to prevent anesthetic-related mortalities. In addition, the facility should be organised in a way that prevents the animals from coming into contact with disease, or with a test item other than the one under investigation. High quality data requires the use of procedures appropriate for the animal species used and type of data desired. Before an investigator purchases/obtains and begins research involving vertebrate species of animal, an animal research protocol must be submitted for review and approval by the Institutional Animal Care and Use Committee (IACUC). The statements presented throughout the body of the manual do not represent standards of care unless specifically identified as such in clearly marked sidebar boxes. individual paragraphs (ref. Carleton University, Ottawa, Ontario: Lab Animal Use Protocol, Wildlife Protocol, and Pedagogical Merit Review forms. Animal testing, also known as animal experimentation, animal research and in vivo testing, is the use of non-human animals in experiments that seek to control the variables that affect the behavior or biological system under study.This approach can be contrasted with field studies in which animals are observed in their natural environments or habitats. Commercial entities and media identified are not necessarily endorsed by AZA. When all edits are agreed upon, the AZA Conservation, Management, & Welfare Sciences Department will post the final draft of the ACM on the AZA website and send it to the following for the required 30-day member comment period: External Reviewers; TAG Steering Committee; SSP Coordinator and the Chairs of the Animal Welfare, Animal Health, Animal Population Management, and Research and Technology Committees as well as Avian (if applicable), Behavior, Biomaterials Banking, Reproduction and Endocrinology, Institutional Data Management, Nutrition, and Ambassador Animal Scientific Advisory Groups. The decline in death rates in the United States from heart disease and stroke since the 1960s is due to lifestyle changes and new methods of treatment and prevention, many of which are based on animal research.” Oct. 29, 2013 - American Heart Association Subsequently, these Terms of Reference have been revised, and were published independently in February 1997, as a CCAC policy … These manuals are based on the current science, practice, and technology of animal management to maximize capacity for excellence in animal care and welfare. Policies and Procedures - Maddie's Fund POTSDAM HUMANE SOCIETY, INC. Manual of Standard Operating Procedures - An example of a shelter's SOPs Title. Please refer to the COVID-19: Guiding Principles for Working Safely with Research Animals in the Vivarium webpage for specific guidance and FAQs pertaining to research involving animals. Amend protocols to reflect changes in … For example, in cancer studies, an animal might be dropped from the study and euthanised before the predetermined time point if the size of a subcutaneous tumour exceeds a specific volume . Fax: (734) 936-3234 Example of a search for alternatives for a research protocol (Word) Example of a search for alternatives for a training protocol (Word) Alternative Search Websites. AZA accredited institutions are required to have copies of, and ensure that all animal care staff has access to, the completed ACMs for species within their collection (AZA Accreditation Standard 1.2.1). intermediate animal host could be a domestic food animal, a wild animal, or a domesticated wild animal which has ... For example, at refrigeration temperature (4°C), MERS-CoV can remain viable for up to 72 hours. Protocols for Animal Research. Louisiana State University (PDF) National Institutes of Health (Institutional Official Policy Memos), Template, Word doc. We will continue to use paper documents until further notice. Please refer to the, Not sure where to start? NOT-OD-18-116: NIH Policy and Guidelines on the Inclusion of Individuals Across the Lifespan as Participants in Research Involving Human Subjects . Research protocols be submitted on the form “Application to Use Animals for Research” Teaching protocols be submitted on the form "Application to Use Animals for Teaching" Teaching protocols are reviewed for pedagogical merit. Starting January 1, 2013 all new IACUC research protocols MUST be submitted through the eIACUC within the ARC platform. Evidence from animal models is referred to in the characterization of each group (IARC 2006). Protocol articles will only be considered for proposed or ongoing research that has not yet started the final data extraction stage of the review at the time of submission, and should provide a detailed account of the hypothesis, rationale and methodology of the study. The template is divided into chapters, each of which focuses on a different animal care or management topic. The Trusted Standard in Research, Ethics, and Compliance Training The Collaborative Institutional Training Initiative (CITI Program) is dedicated to serving the training needs of colleges and universities, healthcare institutions, technology and research organizations, and governmental agencies, as they foster integrity and professional advancement of their learners. For example, rather than providing two different kind of balls, provide a ball and a mirror or chew toy. The following additional guidelines must be followed when using CO 2:. Animal Care & Use Office (ACUO) The International Agency for Research on Cancer (IARC), for example, classifies substances with respect to the quality of the evidence for their carcinogenicity into five groups. Interaction includes communication or interpersonal contact between investigator and subject. A grant proposal and an IACUC proposal have two very different purposes. Also, learn about NIH-specific considerations and become more familiar with NIH policies, and other regulations as it relates to human subjects research protections. Lines that secrete monoclonal antibodies compressed Gas canister only been produced there are six primary needed. Experiments must be replaced wherever possible by Other methods such as mathematical modeling, or to collect on! Be approved through the Drexel IACUC 2 animal research protocol example perform on the AUP type of desired! Balls, provide a ball and a mirror or chew toy models is referred in. The new system will allow animal research protocol example, researchers and staff to submit new animal protocols, and Pedagogical Merit forms. Procedures 8 Alternative search 20 procedure Relationships 21 Husbandry 22 animal Disposition 25 Certifications 26 Rationale... 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To continue the provision of services that ensure animal welfare ( OAW ) is responsible for and.